Rett Syndrome is the most physically disabling of the autism spectrum disorders. It strikes at random in early childhood, affecting little girls almost exclusively, and many girls live into adulthood, requiring total, 24-hour-a-day care. The Rett Syndrome Research Trust (RSRT) is a 501(c)(3) nonprofit organization intensively focused on the development of treatments and cures for Rett Syndrome and related MECP2 disorders.

The 2011 documentary RETT: There is Hope strives to raise awareness and funds for the Rett Syndrome Research Trust to support their mission to reverse Rett Syndrome. Watch the trailer here.